So to further determine the association of PD-L1 with cancer metastatic progression, we studied the subset of 310 patients with localized CRC (pM0), of whom 28 (9.03%) progressed to distant metastases at a median follow-up of 5.14 years (range, 0.06–10.14 years). This evidence concerns the gene CD274 and colorectal carcinoma.