The basis of some of these treatment options is based on the discovery of a number of genes associated with pheochromocytomas, including neurofibromin 1 (NFI), von Hippel-Lindau (VHL), transmembrane 127 (TMEM127), proto-oncogene (RET), and MYC associated factor X (MAX) [5], [6]. Here, MAX is linked to hereditary pheochromocytoma-paraganglioma.