The S100P protein was first identified in the human placenta [23], and has been reported to be overexpressed in multiple types of cancer cells, including breast cancer [13], [24], esophageal cancer [15], colon cancer [19], lung cancer [25], pancreatic cancer [26], [27], prostatic cancer [28], ovarian cancer [29], cholangiocarcinoma [30]–[32], and HCC [33]. This evidence concerns the gene S100P and malignant colon neoplasm.