Hence, HCC patients with S100P expression and p53 mutation had the lowest 5-year survival (P = 0.0017 (Figure 3B), even worse than those with the p53 mutation (+)/S100P (-) (P = 0.01) or p53 mutation (-)/S100P (+) tumors (P = 0.01 and P = 0.035, respectively). This evidence concerns the gene TP53 and hepatocellular carcinoma.