The study of the molecular pathology of PIK3CA-mutated colorectal carcinoma has produced some conflicting results, as displayed in table 1, in particular, its association with CpG Island Methylator Phenotype (CIMP) and O-6-methylguanine-DNA methyltransferase (MGMT) status [12], [13], [17], [18], [21], [25], [28], [29], [30]. The gene discussed is PIK3CA; the disease is colorectal carcinoma.