Recently, Norian et al (2011) [32] reported on the reorganization of the actin cytoskeleton mediated by RhoA in leiomyoma cells, confirming the link between RhoA activation in leiomyoma, while Turcotte et al., 2004 [15], demonstrated that hypoxic up-regulation of VHL is a Rho-A mediated event. Here, VHL is linked to leiomyoma.