VEGFA and neoplasm: Low levels of NO/RNS can directly and indirectly via VEGF enhance angiogenesis by activating MMP-1, MMP-9, and MMP-13 (Ridnour et al., 2007; Ziche and Morbidelli, 2009), MMPs are critical for angiogenesis, as they degrade components of the ECM and pave the way for migration of endothelial cells into the tumor, and of tumor cells out of the tumor to the nearest blood vessel.