In order to escape immune killing, tumor cells activate several mechanisms to control the immune response, which include acquiring defects in the antigen processing and presentation pathways to facilitate evasion from adaptive immune recognition (Rabinovich et al., 2007), secretion of immunosuppressive mediators (e.g., TGFβ, IL-10, IL-13, PGE2), and recruitment of regulatory immune cells (Bui and Schreiber, 2007; Rabinovich et al., 2007). Here, TGFB1 is linked to neoplasm.