EGF and neoplasm: Moreover, TAMs are necessary for metastasis, and their ability to secrete EGF together with the ability of tumor cells to secrete M-CSF/CSF-1 stimulate mutual migration in both cell types (Wyckoff et al., 2004; Condeelis and Pollard, 2006; Coffelt et al., 2009; Hernandez et al., 2009).