For example, it has been shown that cannabinoid-1 receptors agonists disrupt temporal coordination of cell assemblies in the hippocampus, which is reflected in disrupted spontaneous or stimulation-induced theta oscillation and leads to memory deficits (Robbe et al., 2006; Hajós et al., 2008; Hajós and Siok, unpublished observations). Here, CNR1 is linked to memory.