Serine/arginine-rich splicing factor 3 (SRSF3) was found to be downregulated in ACC fibroblasts (Fig. 4a and 4b), which has recently been reported to promote transcription of G1/S phase checkpoint regulators and silencing of SRSF3 caused a G1/S phase arrest (Kurokawa et al., EMBO meeting 2011 abstract). This evidence concerns the gene SRSF3 and adrenal cortex carcinoma.