FHIT and Barrett esophagus: This can also be seen in the radial spokes apparent in the Circos plots (Figures 4B, 4C, 5B, 5C, and S4), and also in the lesions that were detected in all biopsies of an individual (some of which are the most common lesions in BE [21], [23], on chromosomes 9p (CDKN2A) and 3p (FHIT) (Figure S5).