Additionally, in the GSE5460 data set the grade 3 HER2-positive breast cancers were found to have higher NR2F1 transcript levels as compared with the grade 3 HER2-negative breast cancers (Figure 7B, right panel), suggesting a regulatory effect of HER2 amplification on NR2F1 transcript levels. Here, NR2F1 is linked to breast carcinoma.