CDH5 and metastatic neoplasm: Vascular endothelial cadherin (VE-cadherin; also known as cadherin 5) is the most important adhesive component of endothelial adherent junctions [3]; while ectopic expression of VE-cadherin in malignant melanoma cells confers this tumor the capability to form vessel-like structures that contributes to the lack of efficient therapeutic strategies and increases the risk of metastatic disease [4].