Using a mouse model of melanoma lung metastasis, we also present in vivo evidence indicating that targeting PARP strongly reduces metastatic dissemination of melanoma cells, at least in part through inducing a reduction in tumor microvessel density along with changes in the expression pattern of EMT markers (Snail1, vimentin and E-cadherin) within the tumor. The gene discussed is PARP1; the disease is melanoma.