TMEM37 and viral infectious disease: Interestingly, HR-like lesions and PR proteins accumulation could be triggered by P19 in the absence of a viral infection, suggesting that endogenous sRNAs, including siRNAs and miRNAs, which are effectively bound by P19 together with viral-derived siRNAs during infection [43], [49], [67], [76], form one component of the trigger.