Our observations, combined with previously described role of mouse Wnt2 [35], Wnt3a [62] and Drosophila melanogaster WntD [34] in inflammatory response to bacterial infection, support a novel role of a canonical-like WNT pathway in the regulation of innate immunity to control excessive response to pathogens, including virus infection as newly reported in this study. Here, WNT3A is linked to bacterial infectious disease.