Our observations, combined with previously described role of mouse Wnt2 [35], Wnt3a [62] and Drosophila melanogaster WntD [34] in inflammatory response to bacterial infection, support a novel role of a canonical-like WNT pathway in the regulation of innate immunity to control excessive response to pathogens, including virus infection as newly reported in this study. The gene discussed is WNT3A; the disease is viral infectious disease.