APC and cervical squamous intraepithelial neoplasia: These studies include the spatially explicit models proposed by Komarova and Wang [27] to investigate the location within the crypt at which APC mutations arise, by Michor et al. to elucidate the time during tumorigenesis at which CIN arises [28], and by Buske et al. to investigate the changes in tissue dynamics resulting from gains or losses of specific gene functions using an agent-based model [29].