ANGPTL4 and neoplasm: It has been suggested that Angptl4 inhibits VEGF-induced vascular leaks and neoangiogenesis in tumors, while others have shown that Angptl4 hijacks integrin-mediated signaling to maintain an elevated, oncogenic O2:H2O2 ratio and therefore, confers anoikis resistance to tumor cells, suggesting that Angptl4 is an important player in redox-mediated cancer progression (5).