We observed a diet-induced increase in the expression of Notch1 in both the adipose tissue and the liver, and whereas the role of notch1 in tumorigenesis has been well documented [63], recent evidence also suggests that notch1 may play a role in the development of insulin resistance [64] and may also have several other pleiotropic functions in the liver [65]. Here, NOTCH1 is linked to Insulin resistance.