Key transcription factor Ppargc1a was significantly down-regulated in both tissues but particularly in adipose (Figure 3b); which was accompanied by a 2-fold reduction in hepatic expression of the Cl(−)/HCO [3] (−) anion exchanger 2 (Slc4a2), which is critically involved in the development of biliary cirrhosis. The gene discussed is PPARGC1A; the disease is biliary liver cirrhosis.