Interestingly, in addition to the reduced expression of Ppargc1a in obese subjects [47], sustained exposure to saturated fatty acids has been shown to attenuate the expression of Ppargc1a in vitro[50]; and epigenetic studies have shown a negative correlation between Ppargc1a mRNA content and an increase in the methylation of the promoter region of Ppargc1a in the skeletal muscle of patients with type 2 diabetes [51]. Here, PPARGC1A is linked to type 2 diabetes mellitus.