CDH1 and neoplasm: The aberrant expression of EMT-related proteins was higher in the invasive margin than in the tumor center; loss of E-cadherin, 17.9% versus 31.8% (p < 0.0001), nuclear expression of β-catenin, 10.6% versus 12.5% (p < 0.0001), and gain of S100A4, 10.2% versus 15.5% (p < 0.0001), respectively.