AGT and Hypertension: Apart from its vasopressor effect, AngII has been known to trigger vascular inflammation via the activation of NF‐κB and to enhance the transcription of proinflammatory cytokines (eg, MCP‐1).37 We showed that hypertension serves as a risk factor for aortic rupture, whereas vascular inflammation alone could trigger aneurysm formation in S3KO mice.