To understand the role of inflammation in AngII‐induced aneurysm in S3KO mice, we first examined the ex vivo effects of TGF‐β1, steroidal and nonsteroidal anti‐inflammatory drugs (ie, dexamethasone and aspirin, respectively), and an iNOS‐selective inhibitor (ie, aminoguanidine) on iNOS‐mediated NO production in endothelium‐denuded aortic rings. Here, NOS2 is linked to aneurysm.