In this study, we investigated how Chinese herb medicines, especially those “kidney-supplements”, such as Semen Astragali Complanati, Rhizoma Cibotii decoction, Herba Cistanches, and Semen Allii Tuberosi, affected bone development, which was examined by measuring the activity of OPG/RANKL/RANK signaling in rats that had osteoporosis-like symptom induced by OVX. This evidence concerns the gene TNFRSF11A and osteoporosis.