Although there are differences in histopathological features and incidence between SC/ASC and AC subtypes of GBC, our study provided evidence that both SC/ASC and AC have common molecular features, that is, positive expression of CCT2 and PDIA3, and that the expression of CCT2 and PDIA3 in tumor cells correlates with tumor progression and poor prognosis. The gene discussed is PDIA3; the disease is neoplasm.