HSPG2 and gas gangrene: Indeed, a plc-complemented ΔpfoA Δplc mutant (or pfoA-deficient strain) and a pfoA-complemented ΔpfoA Δplc mutant (or plc-deficient strain) of a gas gangrene strain had a decreased ability to induce necrohemorrhagic lesions in a calf intestinal loop assay.