The Amyotrophic Lateral Sclerosis belongs to the C2 class of Neurodegenerative Diseases and includes the under-expressed genes DERL1, NEFH and NEFL. The significant genes belonging to the Neurotrophin signalling pathway (a C2 class of Nervous System) are AKT2, ATF4, BAD, CAMK2A and SH2B3. In addition, we observed under expression of NDUFB2 (FC -2.24) and TRAPPC4 (FC -2.82) genes which have a role in postsynaptic membrane trafficking and are differentially expressed in Parkinson’s disease pathway [22]. Here, SH2B3 is linked to neurodegenerative disease.