NOS3 and coronary artery disorder: Notably, Besler et al. showed that HDL from patient with CAD, in contrast to HDL from healthy subjects, activates endothelial PKCβII, leading to inhibition of Akt-dependent eNOS activating phosphorylation at Ser1177 and increased phosphorylation of eNOS at Thr495, which inhibits eNOS activity [6].