The insulin secretion due to GPR119 activation in insulin resistance was accompanied by significantly increased plasma levels of intact GLP1 already after 5 min (8.6±1.2 vs 3.7±0.9 pg/ml, P=0.004) and levels stayed significantly elevated after 20 min (1.2±0.2 vs 0.6±0.2 pg/ml, P=0.05) (Fig. 1G). The gene discussed is GLP1R; the disease is Insulin resistance.