On the other hand, studies on type 2 diabetics have pointed out that there is a lack of glucagon suppression after an oral glucose load, however preserved suppression after an isoglycemic i.v. glucose infusion (IIGI) (42, 43), pointing to gut factors as potential mediators of dysregulated postprandial glucagon secretion in diabetes. The gene discussed is GCG; the disease is type 2 diabetes mellitus.