TRHR and thyroid gland carcinoma: On the other hand, the genotyped THRB SNP that maps in the hormone binding domain (rs3752874) has shown a combined effect with either the TG-rs2076740 or the TRHR-rs4129682 for thyroid cancer risk, and the interaction effect was more than multiplicative (Pinteraction<0.05 and <0.01 respectively).