In prostate cancer cells, urolithins (A, B, C, and D) inhibited CYP1B1 activity (a target in prostate cancer chemoprevention) in a dose ranging from 1.15 μM (urolithin A) to 137 μM (urolithin D) whereas higher concentrations were needed for CYP1A1 activity inhibition (12.4–2,907 μM). This evidence concerns the gene CYP1A1 and prostate carcinoma.