For example, of the over 40 linkage regions that had been reported in genome-wide linkage studies of BP (Newton, 2007), one of the most prominent implicated chromosome 8q24, a region that includes KCNQ3. The 8q24 region initially reached a logarithm (base 10) of odds (LOD) score of 2.39 in a genome-wide scan by the Johns Hopkins Mood Disorders Research Group (Friddle et al., 2000). This evidence concerns the gene KCNQ3 and mood disorder.