Since endothelial NO⋅ is an important anti-inflammatory molecule and suppresses expression of adhesion molecules such as VCAM-1, ICAM-1 (Lee et al., 2002), a positive association between plasma arginase level or peripheral blood mononuclear cell arginase level and soluble VCAM-1 and ICAM-1 is demonstrated in patients with sickle cell anemia and overweight subjects (Morris et al., 2005; Kim et al., 2012). This evidence concerns the gene VCAM1 and sickle cell disease.