For example, eNOS expression in atherosclerotic arteries and arteries from diabetes mellitus as well as in arteries from aged animals is usually compensatorily increased or not changed (Cosentino et al., 1997; van der Loo et al., 2000; d’Uscio et al., 2001; Ming et al., 2004; Desrois et al., 2010; Rajapakse et al., 2011). Here, NOS3 is linked to diabetes mellitus.