RHOA and endothelial dysfunction: Similarly, pharmacological and genetic inhibition of ROCK, the down-stream kinase of RhoA, showed similar inhibitory effects on arginase activity and endothelial dysfunction in atherosclerotic, diabetic, and angiotensin-II-induced hypertensive animal models (Ming et al., 2004; Shatanawi et al., 2011; Yao et al., 2013).