CD4 and autoimmune disease: Although inflammatory Th17 CD4+ T cells mediate diverse autoimmune diseases, and HFD predisposes autoimmune diseases such as trinitrobenzene sulfonic acid (TNBS) colitis and experimental autoimmune encephalomyelitis (EAE) (Winer et al., 2009b), Th17 CD4+ T cells are not involved in the inflammation of obese mice (Winer et al., 2009a).