Interestingly, Sattler et al. have recently shown that the amount of plasma S1P not bound to HDL and the ratio of non-HDL-bound and HDL-bound S1P in plasma are increased in patients with stable CAD and MI compared to healthy individuals and are correlated to the clinical severity of CAD symptoms (Sattler et al., 2010). Here, MBTPS1 is linked to coronary artery disorder.