HTR1A and Anxiety: Although clinically, development of new 5-HT1A receptor agonists for anxiety disorders (e.g., ipsapirone, gepirone, tandospirone, flesinoxan) failed, the 5-HT1A receptor has received considerable interest as a critical target implied in anxiety (Olivier et al., 1999; Holmes, 2008; Lanfumey et al., 2008; Akimova et al., 2009; Savitz et al., 2009).