A simple entropy analysis (Fuhrman et al., 2000) of HD datasets in which the signal is the change of gene status among three possibilities (up-regulated, down-regulated, no effect) allows genes with low-to-high entropy values to be identified in FOXO-interaction networks (Figure 2; Tables S3–5), which is also true when considering gene subsets such as FOXO3 targets (Paik et al., 2009; Renault et al., 2009; Ro et al., 2012) and potential drug targets (Russ and Lampel, 2005). The gene discussed is FOXO3; the disease is Huntington disease.