In the context of the currently available HD datasets, all of them greatly differing at several levels such as htt gene type, genetic background, cellular context and disease stage, our bias is that genes having moderate to high entropy values may represent candidate targets of higher interest because manipulating their activity could more significantly impact on the homeostasis and survival of specific cell types at a given phase (e.g., early vs. late stage) and site (e.g., brain/neuronal vs. peripheral pathology) of the pathogenic process in HD. Here, HTT is linked to Huntington disease.