PGRMC1 and primary ovarian failure: Progesterone receptor membrane component 1 (PGRMC1) plays a clinically important role in regulating ovarian function as demonstrated by the fact that PGRMC1 levels are reduced in some women with polycystic ovarian syndrome (Schuster et al., 2010) or premature ovarian failure (Mansouri et al., 2008; Schuster et al., 2010).