In severe asthma, the largest change in expression was found in the Th1-related transcription factor, Tbet, and this result is in contrast with data obtained from asthmatic patients [30, 32, 33], possibly due to measurement of mRNA expression in mouse whole lung tissue instead of in PBMCs of asthmatics and/or measurement of mRNA expression instead of protein expression. The gene discussed is TBX21; the disease is asthma.