NOS1 and Sepsis: Further, since activation of NF-κB is linked to induction of iNOS, and since inadequately low levels of •NO—and, indeed, iNOS gene knockout in mice [78]—and NOS inhibitors in clinical trials [79, 80] have been implicated in sepsis morbidity and mortality [81], we adopted the hypothesis that NOS translation may, in contradiction to the common view, actually be depressed in sepsis and NOS catalytic activity ‘‘uncoupled” or malfunctioning.