CBL and hyperinsulinemic hypoglycemia, familial, 4: We propose that this paradox may actually be an index of Cbl/NOS regulation in endotoxaemia and that the high mRNA levels in LPS-only animals may be due to the observed phenomenon of “relaxed control of RNA synthesis” when SAM/methyl groups are deficient [92], as in folate or Cbl deficiency [93], thus consequential on the functional Cbl deficiency of endotoxaemia/sepsis, and more permanent MS inactivation by LPS, discussed earlier.