Previously observed high •NO in sepsis is believed to comprise a greater ratio of the more toxic •NO species, such as peroxynitrite, ONOO- [82], which inhibits eNOS [83], as opposed to more antioxidant/cytotoxic •NO forms, such as S-nitrosothiols/GSNO [84, 85] or •NO itself; although overhigh levels of GSNO also have negative effects in sepsis-like inflammation [85]. Here, NOS3 is linked to Sepsis.