Mean CSF Gas6 concentration was nearly equal in CIS with respect to RR-MS patients (7.8 ± 3.2 ng/mL versus 7.9 ± 3.8, Student's t-test, P = n.s.)but significantly higher in CIS/RR-MS (n = 65; 37 females) patients with respect to controls (n = 40; 22 females) (7.9 ± 3.7 ng/mL versus 6.5 ± 2.4 ng/mL resp., P < 0.03) while plasma Gas6 concentration was not significantly different between groups (Student's t test, P = n.s.)(Figure 1). Here, GAS6 is linked to in situ carcinoma.