When analyzing the possible links between Pg DNA and the clinical variables in patients affected by RA, we found that patients positive for Pg DNA in the sub-gingival plaque had a shorter disease duration (Pg positive 4.2 ± 5.9 years vs. Pg negative 9.3 ± 8.4 years, P = 0.03), and tended to be more commonly smokers compared to patients negative for Pg in the plaque sample (Pg positivity: smokers 88.9% vs. non-smokers 54.5%, P = 0.07). Here, JUP is linked to rheumatoid arthritis.