GSTM1 and Splenomegaly: In bivariate analyses, MAFtrel was significantly: (i) negatively correlated with the D0 Hb (Pearson’s coefficient?=?−2.8, P?=?0.0001), (ii) positively correlated with illness duration (P?=?0.0005), (iii) higher (P?=?0.0005) in patients with D0 moderate anaemia (n?=?16) vs. those without moderate anaemia (n?=?49): 23.3% vs. 6.6% (these %s correspond to MAFt concentrations of 1.9 vs. 0.9 g/L, (iv) higher (P?=?0.0067) in patients with splenomegaly (n?=?24) vs. those without splenomegaly (n?=?41): 18.2% vs. 8.8% (MAFt concentrations of 2.03 vs. 1.05 g/L).