Additionally, low expression of the breast cancer metastasis suppressor 1 (BRMS1) gene – the product of which is a component of the mSin3a family of histone deacetylase (HDAC) complexes – was shown to enhance NPC metastasis both in vitro and in vivo, and to be associated with poor survival of NPC patients [46]. The gene discussed is BRMS1; the disease is nasopharyngeal carcinoma.