Using laboratory experimental rat myocardial infarction, Clarke’s group has demonstrated that insulin-stimulated D[2-3H] glucose uptake was 42% lower in isolated perfused infarcted hearts, was and this was accompanied by a decrease in expression of glucose transporter (GLUT-4), and negatively correlated with ejection fraction and with fasting plasma FFA concentration [21]. Here, INS is linked to myocardial infarction.