PARG and infection: Taking into account that the number of trypomastigotes in the supernatant was the only affected parameter when PARG silenced cells were treated with DEA but that pre-incubation of trypomastigotes in this PARG inhibitor has no effect on the initial infection effectivity of these parasites on Vero cells, we hypothesized that DEA could have a direct effect over T. cruzi amastigote intracellular replication or amastigote to trypomastigote differentiation processes, as well as over the host cell.