TRPS1 and breast cancer: It is intriguing that altering TRPS1 or ADIPOR1 alone is sufficient to modulate an EMT phenotype since there is very little evidence that the two pathways are directly related; however, there are many ways to induce EMT and the fact that miR-221/222 is targeting two independent pathways that, together, are signaling to nodes key for mediating EMT in breast cancer, underscores the importance of our findings and warrants further investigation.