Both the NF-κB/IL6/JAK2/STAT3 cascade, which we show here is modulated by miR-221/222-mediated downregulation of ADIPOR1, and ZEB2 expression, which we have previously shown is repressed by TRPS1, are well-characterized effector pathways in cancer metastasis, invasion, and EMT. Here, TRPS1 is linked to cancer.