One potential limitation of our study is that most of our work was done in two cell lines, MCF10A and MDA-MB-231, and could limit the generalization of our findings; however, the negative correlation between miR-221 and miR-222 expression and ADIPOR1 mRNA expression in breast tumors as well as in breast cancer cell lines suggests that our model could hold true in other systems. Here, ADIPOR1 is linked to breast cancer.