It is intriguing that altering TRPS1 or ADIPOR1 alone is sufficient to modulate an EMT phenotype since there is very little evidence that the two pathways are directly related; however, there are many ways to induce EMT and the fact that miR-221/222 is targeting two independent pathways that, together, are signaling to nodes key for mediating EMT in breast cancer, underscores the importance of our findings and warrants further investigation. Here, TRPS1 is linked to breast carcinoma.