Serum levels of pro-MMP-1 and active MMP-1 were significantly increased in patients with bronchiectasis with 1G/1G genotype (15.0±2.1 pg/ml; 12.5±1.5 pg/ml, respectively, n = 8, p<0.0001) and 1G/2G genotype (11.0±1.0 pg/ml; 9.5±1.1 pg/ml, respectively, n = 24, p<0.0001), compared to those with 2G/2G genotype (4.5±0.5 pg/ml; 3.2±0.3 pg/ml, n = 18) or normal subjects (5.0±0.6 pg/ml; 3.1±0.4 pg/ml, n = 25) (Figure 2A and B). This evidence concerns the gene MMP1 and bronchiectasis.