Accordingly, to examine the species specificity of ginsenosides as AHR agonists, we evaluated their ability to induce DRE-luciferase gene expression in stably transfected rat (H4L1.1c4), mouse (H1L1.1c2) and human (HG2L6.1c3) hepatoma cell lines. This evidence concerns the gene AHR and hepatocellular carcinoma.