In the multivariable analysis (Table 2), factors independently associated with a higher incidence of CKD were: older age, female gender, history or presence of diabetes, history or presence of hyperlipidemia, history or presence of high blood pressure, current CD4+ lymphocytes cell count <200/mm3, AIDS stage, baseline creatinine clearance <80 ml/mn and exposure to tenofovir (IRR = 2.0; 95% CI [1.4–2.8]). The gene discussed is CD4; the disease is hyperlipidemia.