To test this hypothesis, we performed mutation analysis of the open reading frame of TUSC1(GenBank: AY168647) on 97 genomic DNA samples including 45 cancer cell lines (22 lung, 17 melanoma and six colon), 14 matched NSCLC cell line pairs, six matched Small Cell Lung Cancer (SCLC) cell line pairs and six matched SCLC primary tumors. This evidence concerns the gene TUSC1 and small cell lung carcinoma.