Further, the eIF4H gene expression and protein content correlated with the level of p65 DNA binding activity in different cancer cell lines, such as breast cancer (MDA-MB-231, MCF7), neuroblastoma (SH-SY5Y), glioblastoma (U251, D54) and B-cell lymphoma (MC3, DeFew), supporting the role of p65 as transcriptional activator of eIF4H in different cellular contexts (Figure 1F - H). Here, RELA is linked to breast cancer.