Many studies implicate Cdk2 as a key regulator in several centrosomal functions including: centrosome duplication [17], [32]–[35], CA in p53-negative breast cancer cells [36] and p53-null mouse embryonic fibroblasts [26], [37], [38], and cells expressing the E7 viral oncoprotein [39]. The gene discussed is CDK2; the disease is breast cancer.