NF1 and Familial prostate cancer: The upregulated miRNAs in our studies include miR-21, which targets PTEN in non-small cell lung cancer [54]; cluster miR-221/miR-222, which is activated in Schwann cell proliferation following sciatic nerve injury by targeting LASS2[55] and accelerates proliferation during liver regeneration [56]; and miR-370, which is capable of reducing NF1 mRNA levels in acute myeloid leukemia [57] and is also overexpressed in prostate cancer [58].