The impairment of axonal transport is an early and perhaps causative event in many neurodegenerative diseases, and might be due to alterations and/or loss of motor proteins (kinesin and dynein), microtubules, cargoes (by inhibiting their attachment to motor proteins) and ATP fuel supply (mitochondria) which enables molecular motors to undertake the axonal transport [7]. This evidence concerns the gene IMMT and neurodegenerative disease.