Therefore, the goal of this work, was to evaluate the impact of early diabetes in the hippocampus, namely in the content and distribution of KIF1A (kinesin that transports synaptic vesicle precursors containing synaptophysin and synaptotagmin), KIF5B (kinesin that transports mitochondria and membrane organelles that contain presynaptic membrane proteins such as syntaxin-1 and SNAP-25) and dynein (motor protein responsible for the retrograde axonal transport of organelles, such as mitochondria). Here, KIF1A is linked to diabetes mellitus.