To our knowledge, the effect of diabetes on the expression and content of motor proteins in the hippocampus has never been addressed, and so we analyzed mRNA levels and the content of KIF1A and KIF5B in hippocampal total extracts by western blotting, as well as the immunoreactivity of both proteins in hippocampal Cornu Ammonis (CA1 and CA3) and dentate gyrus (DG) subregions. The gene discussed is KIF1A; the disease is diabetes mellitus.